منابع مشابه
Multivesicular bodies
theoreticians in developmental biology, as mainstream opinion held that one had to clone the genes involved and isolate the corresponding molecules — and that development would then be understood. The interest in theories was correspondingly low. At this time, the fascinating and beautiful patterns on shells were for me an inspiring looking glass to study the richness of patterns that can emerg...
متن کاملWnt Signaling: Multivesicular Bodies Hold GSK3 Captive
Two key events in Wnt signal transduction, receptor endocytosis and inactivation of Glycogen Synthase Kinase 3 (GSK3), remain incompletely understood. Taelman et al. (2010) discover that Wnt signaling inactivates GSK3 by sequestering the enzyme in multivesicular bodies, thus linking these two events and providing a new framework for understanding Wnt signaling.
متن کاملCargo sorting into multivesicular bodies in vitro.
Genetic studies have identified a number of proteins required for the internalization of biosynthetic and endocytic cargo proteins transported to the multivesicular body (MVB). We have developed a cell-free reaction that recapitulates the internalization of a yeast biosynthetic membrane cargo protein, carboxypeptidase S (CPS), into the interior of an endosome. A recombinant form of CPS containi...
متن کاملMegakaryocyte dense granule components are sorted in multivesicular bodies.
Recent studies suggest that multivesicular bodies are an intermediate stage in the formation of alpha-granules. In contrast, the kinetics and mode of appearance of dense granules during megakaryocytic maturation has remained poorly understood. Immunoelectron microscopy was used to monitor the appearance of dense granular markers (granulophysin and serotonin) on cryosections of human megakaryocy...
متن کاملIsoform-specific targeting of PKA to multivesicular bodies
Although RII protein kinase A (PKA) regulatory subunits are constitutively localized to discrete cellular compartments through binding to A-kinase-anchoring proteins (AKAPs), RI subunits are primarily diffuse in the cytoplasm. In this paper, we report a novel AKAP-dependent localization of RIα to distinct organelles, specifically, multivesicular bodies (MVBs). This localization depends on bindi...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2008
ISSN: 0960-9822
DOI: 10.1016/j.cub.2008.02.068